171 Amphiphysin ii (bin1) driven transverse tubule formation in cardiac muscle
نویسندگان
چکیده
منابع مشابه
Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1).
RATIONALE Transverse tubules (t-tubules) regulate cardiac excitation-contraction coupling and exhibit interchamber and interspecies differences in expression. In cardiac disease, t-tubule loss occurs and affects the systolic calcium transient. However, the mechanisms controlling t-tubule maintenance and whether these factors differ between species, cardiac chambers, and in a disease setting rem...
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Bin1/M-amphiphysin-II is an amphiphysin-II isoform highly expressed in transverse tubules of adult striated muscle and is implicated in their biogenesis. Bin1 contains a basic unique amino-acid sequence, Exon10, which interacts with certain phosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)), to localize to membranes. Here we found that Exon10 also binds to the src hom...
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In tubular muscle fibers of the yellow scorpion the transverse tubules are arranged in a radial symmetry. This particular morphology, enables one to derive values for electrical components of one transverse tubule (TT) by treating the TT as a core conductor rather than a complex network. The electrical properties of tubular muscle fibers were completely characterized and analyzed by measuring t...
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Drosophila Nedd4 (dNedd4) is a HECT ubiquitin ligase with two main splice isoforms: dNedd4-short (dNedd4S) and -long (dNedd4Lo). DNedd4Lo has a unique N-terminus containing a Pro-rich region. We previously showed that whereas dNedd4S promotes neuromuscular synaptogenesis, dNedd4Lo inhibits it and impairs larval locomotion. To delineate the cause of the impaired locomotion, we searched for bindi...
متن کاملAmphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in Skeletal Muscle
Amphiphysin (amphiphysin I), a dominant autoantigen in paraneoplastic Stiff-man syndrome, is a neuronal protein highly concentrated in nerve terminals, where it has a putative role in endocytosis. The yeast homologue of amphiphysin, Rvs167, has pleiotropic functions, including a role in endocytosis and in actin dynamics, suggesting that amphiphysin may also be implicated in the function of the ...
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ژورنال
عنوان ژورنال: Heart
سال: 2017
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2017-311726.169